Chemonucleolysis: anatomical, radiological and clinical aspects

In this thesis the findings and results are reported of three studies on the anatomical, radiological and clinical aspects of chemonucleolysis for the treatment of lumbar intervertebral disc herniation. The objectives of these studies are described in Chapter 1. Many experimental studies on the pharmacology, toxicology and biomechanical effects of intra-discal chymopapain administration have elucidated part of its (possible) mode of action, but many questions relevant to clinicapl ractice still remain. ... Zie: Summary